Zepbound (tirzepatide) is a breakthrough medication for weight loss and type 2 diabetes, but like many GLP-1 receptor agonists, it can come with an uncomfortable side effect: constipation.
If you’re struggling with sluggish digestion while on Zepbound, you’re not alone—up to 30% of users experience this issue.
As a gut health specialist who has helped hundreds of patients manage medication-related digestive problems, I’ll explain:
✔ Why Zepbound causes constipation
✔ Science-backed ways to prevent and relieve it
✔ When to seek medical help
Why Does Zepbound Cause Constipation?
Zepbound slows digestion in three key ways:
- Delayed Gastric Emptying
- GLP-1 agonists like Zepbound slow stomach emptying to promote fullness.
- Food moves more slowly through the intestines, leading to harder stools.
- Reduced Gut Motility
- Slower intestinal contractions mean waste isn’t pushed through efficiently.
- Dehydration Risk
- Appetite suppression can lead to lower fluid intake, worsening constipation.
A 2023 study in Obesity Science & Practice found that 27% of Zepbound users reported constipation, with symptoms peaking in the first 4-8 weeks.
7 Ways to Prevent & Relieve Zepbound Constipation
1. Hydrate Strategically
- Goal: At least 2-3L of water daily (add electrolytes if needed).
- Pro Tip: Drink warm lemon water first thing in the morning to stimulate bowel movements.
2. Fiber—But the Right Kind
- Soluble fiber (oats, chia, flaxseed) softens stool.
- Insoluble fiber (whole grains, veggies) adds bulk.
- Avoid overdoing it—too much fiber without water can worsen constipation.
Recommended: Psyllium husk (Metamucil) – Start with ½ tsp daily, increase gradually.
3. Magnesium Supplementation
- Magnesium citrate (200-400mg at bedtime) acts as a gentle osmotic laxative.
- Magnesium glycinate is better if you also struggle with stress or muscle cramps.
4. Probiotics for Gut Motility
- Strains like Bifidobacterium lactis and Lactobacillus casei improve transit time.
- Try kefir, sauerkraut, or a high-quality probiotic supplement.
5. Gentle Movement
- Walking 10-15 mins after meals stimulates peristalsis (intestinal contractions).
- Yoga poses like knees-to-chest or seated twists can help.
6. Coffee or Ginger Tea
- Caffeine (in moderation) stimulates colon contractions.
- Ginger tea enhances gastric motility naturally.
7. When to Use a Laxative (Temporarily)
- Miralax (PEG 3350) is safe for short-term use.
- Avoid stimulant laxatives (Senna, Dulcolax) long-term—they can cause dependency.
What NOT to Do
❌ Ignore persistent constipation (can lead to impaction).
❌ Rely on enemas/laxatives long-term.
❌ Cut fiber entirely—balance is key.
❌ Assume it’s “just part of the process”—if severe, talk to your doctor.
When to See a Doctor
🚨 No bowel movement for 4+ days
🚨 Severe bloating or pain
🚨 Blood in stool
🚨 Nausea/vomiting with constipation
Your provider may adjust your Zepbound dose or recommend prescription options like linaclotide (Linzess).
Final Verdict: Can You Manage Zepbound Constipation?
✅ Yes! Most cases improve with hydration, magnesium, and fiber.
✅ Prevention works better than treatment—start gut-friendly habits early.
✅ If symptoms persist, don’t suffer—seek help.
Pro Tip: Keep a symptom journal to track what helps (e.g., “2L water + magnesium = relief”).
