Does Ozempic Need to be Refrigerated?

Ozempic, a medication commonly prescribed for treating type 2 diabetes, is no exception. In this comprehensive article, we will delve into the storage requirements for Ozempic, addressing the crucial question: Does Ozempic need to be refrigerated?

Quick Summary

Yes, Ozempic needs to be refrigerated between 36°F and 46°F (2°C and 8°C) until its expiration date.

What is Ozempic?

Ozempic, also known as semaglutide, is a glucagon-like peptide-1 (GLP-1) receptor agonist medication used to improve glycemic control in adults with type 2 diabetes.

It works by stimulating insulin release from the pancreas, which helps lower blood sugar levels. Ozempic is administered as a subcutaneous injection, typically once weekly, and is effective in reducing HbA1c levels and promoting weight loss in individuals with type 2 diabetes.

Storage Requirements for Medication

Proper storage of medications is essential to maintain their potency, stability, and safety. Factors such as temperature, humidity, and exposure to light can all impact the integrity of a medication.

Manufacturers often provide specific storage instructions to ensure their products’ optimal performance and shelf life.

Why Does Ozempic Need to be Refrigerated?

Ozempic is a peptide-based medication. Like many other peptide-based drugs, it is sensitive to temperature fluctuations and degradation.

Storing Ozempic at the recommended refrigeration temperature helps to maintain the stability of the active ingredient, semaglutide, and prevents it from breaking down prematurely.

How to Store Ozempic Properly?

To store Ozempic properly, follow these guidelines:

  1. Keep the Ozempic pen in the refrigerator at a temperature between 36°F and 46°F (2°C and 8°C).
  2. Avoid exposing them to direct sunlight or heat sources, as this can accelerate the degradation of the medication.
  3. Once used, it can be kept at room temperature (below 86°F or 30°C) for up to 56 days. However, it is still recommended that it be returned to the refrigerator when not in use.
  4. Do not freeze the Ozempic pen, as this can also compromise the stability of the medication.

What Happens if Ozempic is Not Stored Correctly?

If Ozempic is not stored at the recommended refrigeration temperature, the medication may degrade, reducing its effectiveness and potency.

Exposure to heat, sunlight, or freezing temperatures can cause the active ingredient, semaglutide, to break down, rendering the medication less effective or potentially unsafe.

Alternatives to Refrigeration for Storing Ozempic

In some cases, where refrigeration may not be readily available, there are alternative storage options for Ozempic. However, these options should be used with caution and only for short periods:

  • Room Temperature Storage: Ozempic can be stored at room temperature (below 86°F or 30°C) for up to 56 days, but it is still recommended to be returned to the refrigerator when not in use.
  • Insulated Bag: An insulated bag with ice packs can help maintain the proper temperature for the Ozempic during short travel periods or when refrigeration is unavailable.


In conclusion, Ozempic, a medication used to treat type 2 diabetes, requires refrigeration to maintain its potency and effectiveness.

Storing Ozempic at the recommended temperature range of 36°F to 46°F (2°C to 8°C) is crucial to preserving the active ingredient and ensuring the medication remains safe and reliable for use.

By following the proper storage guidelines, individuals with type 2 diabetes can ensure that their Ozempic medication is stored correctly and ready for use when needed.

Please consult with your healthcare provider or a registered pharmacist to learn more about Ozempic and how to store and handle it properly.

They can provide personalized guidance and recommendations to ensure you get the most out of your Ozempic treatment.