Magnesium L-threonate (Magtein®) is one of the most effective forms of magnesium for cognitive function, memory, and deep sleep—thanks to its unique ability to cross the blood-brain barrier48.
If you’re looking for the best magnesium L-threonate supplements to boost brainpower, reduce anxiety, or improve sleep, this guide compares top-rated brands based on purity, dosage, absorption, and customer reviews.
Why Magnesium L-Threonate?
Unlike regular magnesium, L-threonate is specifically designed to increase magnesium levels in the brain, making it ideal for:
✔ Memory & learning (supports synaptic plasticity)8
✔ Deep sleep (enhances REM and restorative sleep)4
✔ ADHD & focus (may reduce symptoms by 25%)8
✔ Anxiety & stress relief (regulates GABA and cortisol)4
10 Best Magnesium L-Threonate Supplements of 2025
Here, we present the top 10 Magnesium L-Threonate supplements available, starting with our top pick:
Cymbiotika Magnesium L-Threonate
Cymbiotika’s Magnesium L-Threonate stands out for its innovative liposomal delivery system, which enhances the bioavailability of magnesium, ensuring optimal absorption.
This formulation is designed to support brain health, improve cognitive functions, and promote restful sleep. Additionally, Cymbiotika emphasizes the use of high-quality, non-GMO ingredients, catering to health-conscious consumers.
Life Extension Neuro-Mag Magnesium L-Threonate
Life Extension’s Neuro-Mag offers a highly absorbable form of Magnesium L-Threonate, specifically formulated to support cognitive function and memory.
Each serving provides 144 mg of magnesium, and the product is praised for its vegetarian-friendly composition and absence of genetically modified ingredients.
Double Wood Supplements Magnesium L-Threonate
Double Wood Supplements provides a Magnesium L-Threonate product that boasts high absorption rates, thanks to its Magtein formulation.
It’s designed to support cognitive function, enhance sleep quality, and promote overall brain health. Users appreciate its non-GMO certification and the fact that it’s manufactured in the USA.
NOW Foods Magtein Magnesium L-Threonate
NOW Foods offers Magtein Magnesium L-Threonate capsules that aim to support cognitive function and brain health.
Known for their commitment to quality, NOW Foods ensures that this supplement is free from common allergens and is suitable for vegetarians. Each serving delivers a significant dose of bioavailable magnesium.
Jarrow Formulas MagMind
Jarrow Formulas’ MagMind features Magnesium L-Threonate intended to support brain health and cognitive function. The product is designed for easy absorption and is suitable for vegetarians. Users have reported improvements in memory and mental clarity with regular use.
Doctor’s Best Brain Magnesium
Doctor’s Best offers a Brain Magnesium supplement containing Magtein Magnesium L-Threonate. This product is formulated to support cognitive function, memory, and overall brain health. It’s non-GMO, gluten-free, and suitable for vegetarians, making it accessible to a wide range of users.
Source Naturals Magtein
Source Naturals’ Magtein provides Magnesium L-Threonate to support learning and memory. The supplement is designed for optimal absorption and is free from artificial additives. Users have noted enhanced cognitive performance and reduced mental fatigue.
Nutricost Magnesium L-Threonate
Nutricost offers a Magnesium L-Threonate supplement that provides a potent dose per serving. It’s formulated to support cognitive function and brain health. The product is non-GMO and gluten-free, catering to those with dietary restrictions.
Pure Encapsulations CogniMag
Pure Encapsulations’ CogniMag combines Magnesium L-Threonate with other cognitive-supporting ingredients. Known for their commitment to purity and quality, this supplement is free from common allergens and artificial additives. Users have reported improvements in focus and mental clarity.
Vital Nutrients Magnesium Threonate
Vital Nutrients provides a Magnesium Threonate supplement aimed at supporting cognitive function and brain health. The product is tested for purity and potency, ensuring high-quality supplementation. It’s free from gluten, dairy, and soy, making it suitable for individuals with specific dietary needs.
How to Choose the Best Magnesium L-Threonate Supplement
When selecting a magnesium L-threonate supplement, consider:
✔ Form (capsules, powder, liquid)
✔ Elemental magnesium content (not just total mg)
✔ Third-party testing (NSF, USP, or ConsumerLab verified)
✔ Additional ingredients (glycinate, taurate, or nootropics)
Final Verdict
For premium quality, Cymbiotika’s Magnesium L-Threonate is our top pick due to its purity and cognitive benefits. If you’re on a budget, Double Wood Supplements offers great value.
Incorporating Magnesium L-Threonate into your daily regimen may offer significant benefits for cognitive function and overall brain health.
The supplements listed above have been selected based on their quality, bioavailability, and positive user feedback. As always, it’s advisable to consult with a healthcare professional before starting any new supplement to ensure it aligns with your individual health needs.
